1k12

Structural highlights

Function

FUCL_ANGAN Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Wu AM, Wu JH, Singh T, Liu JH, Herp A. Lectinochemical studies on the affinity of Anguilla anguilla agglutinin for mammalian glycotopes. Life Sci. 2004 Jul 16;75(9):1085-103. PMID:15207656 doi:http://dx.doi.org/10.1016/j.lfs.2004.02.016
2. ↑ Bianchet MA, Odom EW, Vasta GR, Amzel LM. A novel fucose recognition fold involved in innate immunity. Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873 doi:10.1038/nsb817