1m0u

From Proteopedia

Crystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with Glutathione

Structural highlights

1m0u is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.75Å
Ligands:	GSH, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GSTS1_DROME Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:1445191, PubMed:12547198).^[1] ^[2] ^[3]

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Agianian B, Tucker PA, Schouten A, Leonard K, Bullard B, Gros P. Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products. J Mol Biol. 2003 Feb 7;326(1):151-65. PMID:12547198
↑ Beall C, Fyrberg C, Song S, Fyrberg E. Isolation of a Drosophila gene encoding glutathione S-transferase. Biochem Genet. 1992 Oct;30(9-10):515-27. PMID:1445191 doi:10.1007/BF01037590
↑ Saisawang C, Wongsantichon J, Ketterman AJ. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Biochem J. 2012 Feb 15;442(1):181-90. doi: 10.1042/BJ20111747. PMID:22082028 doi:http://dx.doi.org/10.1042/BJ20111747

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 See Also
5 References

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PDB ID 1m0u

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1m0u

From Proteopedia

Crystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with Glutathione

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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