1nkw
From Proteopedia
Crystal Structure Of The Large Ribosomal Subunit From Deinococcus Radiodurans
Structural highlights
FunctionRL2_DEIRA One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_B] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedWe describe the high resolution structure of the large ribosomal subunit from Deinococcus radiodurans (D50S), a gram-positive mesophile suitable for binding of antibiotics and functionally relevant ligands. The over-all structure of D50S is similar to that from the archae bacterium Haloarcula marismortui (H50S); however, a detailed comparison revealed significant differences, for example, in the orientation of nucleotides in peptidyl transferase center and in the structures of many ribosomal proteins. Analysis of ribosomal features involved in dynamic aspects of protein biosynthesis that are partially or fully disordered in H50S revealed the conformations of intersubunit bridges in unbound subunits, suggesting how they may change upon subunit association and how movements of the L1-stalk may facilitate the exit of tRNA. High resolution structure of the large ribosomal subunit from a mesophilic eubacterium.,Harms J, Schluenzen F, Zarivach R, Bashan A, Gat S, Agmon I, Bartels H, Franceschi F, Yonath A Cell. 2001 Nov 30;107(5):679-88. PMID:11733066[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also
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Categories: Deinococcus radiodurans | Large Structures | Agmon I | Bartels H | Bashan A | Franceschi F | Gat S | Harms JM | Schluenzen F | Yonath A | Zarivach R
