1ntj

Structural highlights

Function

CR1L_RAT Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Antic Stankovic J, Vucevic D, Majstorovic I, Vasilijic S, Colic M. The role of rat Crry, a complement regulatory protein, in proliferation of thymocytes. Life Sci. 2004 Nov 5;75(25):3053-62. PMID:15474557 doi:10.1016/j.lfs.2004.06.007
2. ↑ Quigg RJ, Holers VM, Morgan BP, Sneed AE 3rd. Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis. J Immunol. 1995 Apr 1;154(7):3437-43 PMID:7534798
3. ↑ Takizawa H, Okada N, Okada H. Complement inhibitor of rat cell membrane resembling mouse Crry/p65. J Immunol. 1994 Mar 15;152(6):3032-8 PMID:8144902