1nw1

Structural highlights

Function

CKA2_CAEEL Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Choline kinase 3D structures
• Hemoglobin 3D structures

References

1. ↑ Gee P, Kent C. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Biochim Biophys Acta. 2003 May 30;1648(1-2):33-42. PMID:12758145 doi:10.1016/s1570-9639(03)00106-7
2. ↑ Yuan C, Kent C. Identification of critical residues of choline kinase A2 from Caenorhabditis elegans. J Biol Chem. 2004 Apr 23;279(17):17801-9. PMID:14960577 doi:10.1074/jbc.M401382200