1pop

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X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX

Structural highlights

1pop is a 2 chain structure with sequence from Carica papaya and Streptomyces roseus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:ACE, AR7, MOH
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PAPA1_CARPA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structure of the papain-leupeptin complex has been determined by X-ray crystallography to a resolution of 2.1 A (overall R-factor = 19.8%). The structure indicates that: (i) leupeptin contacts the S subsites of the papain active site and not the S' subsites; (ii) the 'carbonyl' carbon atom of the inhibitor is covalently bound by the Cys-25 sulphur atom of papain and is tetrahedrally coordinated; (iii) the 'carbonyl' oxygen atom of the inhibitor faces the oxyanion hole and makes hydrogen bond contacts with Gln-19 and Cys-25.

X-ray crystallographic structure of a papain-leupeptin complex.,Schroder E, Phillips C, Garman E, Harlos K, Crawford C FEBS Lett. 1993 Jan 2;315(1):38-42. PMID:8416808[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
8 reviews cite this structure
The lysosomal cysteine proteases.
McGrath et al. (1999)
7 more
48 other articles
No citations found

See Also

References

  1. ↑ Schroder E, Phillips C, Garman E, Harlos K, Crawford C. X-ray crystallographic structure of a papain-leupeptin complex. FEBS Lett. 1993 Jan 2;315(1):38-42. PMID:8416808

Contents


PDB ID 1pop

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OCA

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