1up5

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Chicken Calmodulin

Structural highlights

1up5 is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:CA, M3L
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CALM_CHICK Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Two new crystal forms of calmodulin from Gallus gallus are reported. Crystals in space group P1 (cell dimensions a = 59.7, b = 53.1, c = 24.6 A, alpha = 93.2, beta = 96.7, gamma = 89.2 and Z = 2), grow as long thin needles. Water content on density considerations is approximately 50%. They diffract to approximately 2.0 A but give wide multiply peaked spot profiles. Crystals in space group P2(1)2(1)2(1) (cell dimensions a = 32.2, b = 56.0, c = 67.3 A and Z = 4), grow as clusters of thin tablets and contain approximately 30% water by volume. These small crystals ( approximately 0.4 x 0.15 x 0.1 mm) diffracted well to approximately 1.4 A and some appreciable intensities were observed at resolutions better than 1.2 A.

Crystallization and preliminary X-ray analysis of two new crystal forms of calmodulin.,Rupp B, Marshak DR, Parkin S Acta Crystallogr D Biol Crystallogr. 1996 Mar 1;52(Pt 2):411-3. PMID:15299715[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
3 reviews cite this structure
Structural basis for diversity of the EF-hand calcium-binding proteins.
Grabarek et al. (2006)
2 more
11 other articles
No citations found

See Also

References

  1. ↑ Rupp B, Marshak DR, Parkin S. Crystallization and preliminary X-ray analysis of two new crystal forms of calmodulin. Acta Crystallogr D Biol Crystallogr. 1996 Mar 1;52(Pt 2):411-3. PMID:15299715 doi:10.1107/S0907444995011826

Contents


PDB ID 1up5

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OCA

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