1wae

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Crystal structure of H129V Mutant of Alcaligenes Xylosoxidans Nitrite Reductase

Structural highlights

1wae is a 1 chain structure with sequence from Achromobacter xylosoxidans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:CU, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O68601_ALCXX

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Copper nitrite reductases contain both an electron-transfer type 1 Cu site and a catalytic type 2 Cu site. We have mutated one of the type 2 copper ligating histidines to observe the effect on catalytic turnover. This mutation has created a unique site where Cu is ligated by 2 His Nepsilon2 atoms alone.

Observation of an unprecedented Cu Bis-His site: crystal structure of the H129V mutant of nitrite reductase.,Ellis MJ, Antonyuk SV, Strange RW, Sawers G, Eady RR, Hasnain SS Inorg Chem. 2004 Nov 29;43(24):7591-3. PMID:15554622[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
2 reviews cite this structure
Binding and activation of nitrite and nitric oxide by copper nitrite reductase and corresponding model complexes.
Merkle et al. (2012)
1 more
4 other articles
No citations found

See Also

References

  1. ↑ Ellis MJ, Antonyuk SV, Strange RW, Sawers G, Eady RR, Hasnain SS. Observation of an unprecedented Cu Bis-His site: crystal structure of the H129V mutant of nitrite reductase. Inorg Chem. 2004 Nov 29;43(24):7591-3. PMID:15554622 doi:10.1021/ic048966p

Contents


PDB ID 1wae

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