1wfa

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WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT 4 DEGREES C

Structural highlights

1wfa is a 2 chain structure with sequence from Pseudopleuronectes americanus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:NH2
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ANPA_PSEAM Antifreeze proteins lower the blood freezing point.

Publication Abstract from PubMed

Antifreeze proteins provide fish with protection against the freezing effect of polar environments by binding to ice surfaces and inhibiting growth of ice crystals. We present the X-ray crystal structure at 1.5 A resolution of a lone alpha-helical antifreeze protein from winter flounder, which provides a detailed look at its ice-binding features. These consist of four repeated ice-binding motifs, the side chains of which are inherently rigid or restrained by pair-wise side-chain interactions to form a flat binding surface. Elaborate amino- and carboxy-terminal cap structures are also present, which explain the protein's rich alpha-helical content in solution. We propose an ice-binding model that accounts for the binding specificity of the antifreeze protein along the <0112> axes of the (2021) ice planes.

Ice-binding structure and mechanism of an antifreeze protein from winter flounder.,Sicheri F, Yang DS Nature. 1995 Jun 1;375(6530):427-31. PMID:7760940[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
27 reviews cite this structure
Antifreeze proteins of teleost fishes.
Fletcher et al. (2001)
26 more
131 other articles
No citations found

See Also

References

  1. ↑ Sicheri F, Yang DS. Ice-binding structure and mechanism of an antifreeze protein from winter flounder. Nature. 1995 Jun 1;375(6530):427-31. PMID:7760940 doi:http://dx.doi.org/10.1038/375427a0

Contents


PDB ID 1wfa

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