1x0s

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Crystal structure of the 13-cis isomer of bacteriorhodopsin

Structural highlights

1x0s is a 1 chain structure with sequence from Halobacterium salinarum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:GAL, GLC, L2P, L3P, MAN, RET, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BACR_HALSA Light-driven proton pump.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The atomic structure of the trans isomer of bacteriorhodopsin was determined previously by using a 3D crystal belonging to the space group P622. Here, a structure is reported for another isomer with the 13-cis, 15-syn retinal in a dark-adapted crystal. Structural comparison of the two isomers indicates that retinal isomerization around the C13[double bond]C14 and the C15[double bond]N bonds is accompanied by noticeable displacements of a few residues in the vicinity of the retinal Schiff base and small re-arrangement of the hydrogen-bonding network in the proton release channel. On the other hand, aromatic residues surrounding the retinal polyene chain were found to scarcely move during the dark/light adaptation. This result suggests that variation in the structural rigidity within the retinal-binding pocket is one of the important factors ensuring the stereospecific isomerization of retinal.

Crystal structure of the 13-cis isomer of bacteriorhodopsin in the dark-adapted state.,Nishikawa T, Murakami M, Kouyama T J Mol Biol. 2005 Sep 16;352(2):319-28. PMID:16084526[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
3 reviews cite this structure
Bacteriorhodopsin: Would the real structural intermediates please stand up?
Wickstrand et al. (2015)
2 more
11 other articles
No citations found

See Also

References

  1. ↑ Nishikawa T, Murakami M, Kouyama T. Crystal structure of the 13-cis isomer of bacteriorhodopsin in the dark-adapted state. J Mol Biol. 2005 Sep 16;352(2):319-28. PMID:16084526 doi:10.1016/j.jmb.2005.07.021

Contents


PDB ID 1x0s

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OCA

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