Structural highlights
Function
PPK1_ECOLI Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can use GTP instead of ATP, but the efficiency of GTP is 5% that of ATP. Also exhibits several other enzymatic activities, which include: ATP synthesis from polyP in the presence of excess ADP, general nucleoside-diphosphate kinase activity, linear guanosine 5'-tetraphosphate (ppppG) synthesis and autophosphorylation.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Tzeng CM, Kornberg A. The multiple activities of polyphosphate kinase of Escherichia coli and their subunit structure determined by radiation target analysis. J Biol Chem. 2000 Feb 11;275(6):3977-83. PMID:10660553 doi:10.1074/jbc.275.6.3977
- ↑ Kumble KD, Ahn K, Kornberg A. Phosphohistidyl active sites in polyphosphate kinase of Escherichia coli. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14391-5. PMID:8962061
