1zag
From Proteopedia
HUMAN ZINC-ALPHA-2-GLYCOPROTEIN
Structural highlights
FunctionZA2G_HUMAN Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedZn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 angstrom crystal structure of ZAG resembles a class I major histocompatibility complex (MHC) heavy chain, but ZAG does not bind the class I light chain beta2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a nonpeptidic compound that may be implicated in lipid catabolism under normal or pathological conditions. Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.,Sanchez LM, Chirino AJ, Bjorkman P Science. 1999 Mar 19;283(5409):1914-9. PMID:10206894[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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