Structural highlights
Function
CASS4_HUMAN Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Singh MK, Dadke D, Nicolas E, Serebriiskii IG, Apostolou S, Canutescu A, Egleston BL, Golemis EA. A novel Cas family member, HEPL, regulates FAK and cell spreading. Mol Biol Cell. 2008 Apr;19(4):1627-36. Epub 2008 Feb 6. PMID:18256281 doi:E07-09-0953