2d9s
From Proteopedia
Solution structure of RSGI RUH-049, a UBA domain from mouse cDNA
Structural highlights
DiseaseCBL_MOUSE Note=Can be converted to an oncogenic protein by deletions or mutations that disturb its ability to down-regulate RTKs. FunctionCBL_MOUSE Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-737 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.[1] [2] [3] [4] [5] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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Categories: Large Structures | Mus musculus | Guntert P | Hamada T | Hirota H | Izumi K | Kigawa T | Koshiba S | Kurosaki C | Lin Y-J | Yokoyama S | Yoshida M
