Structural highlights
Function
CVC2_HHV11 Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP. May mediate the capsid docking to the nuclear pore allowing entry of the viral genome into the host nucleus through binding to host nucleoporins NUP214.[HAMAP-Rule:MF_04025][1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Preston VG, Murray J, Preston CM, McDougall IM, Stow ND. The UL25 gene product of herpes simplex virus type 1 is involved in uncoating of the viral genome. J Virol. 2008 Jul;82(13):6654-66. doi: 10.1128/JVI.00257-08. Epub 2008 Apr 30. PMID:18448531 doi:http://dx.doi.org/10.1128/JVI.00257-08
- ↑ Cockrell SK, Sanchez ME, Erazo A, Homa FL. Role of the UL25 protein in herpes simplex virus DNA encapsidation. J Virol. 2009 Jan;83(1):47-57. doi: 10.1128/JVI.01889-08. Epub 2008 Oct 22. PMID:18945788 doi:http://dx.doi.org/10.1128/JVI.01889-08
