2i42

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Crystal structure of Yersinia protein tyrosine phosphatase complexed with vanadate, a transition state analogue

Structural highlights

2i42 is a 1 chain structure with sequence from Yersinia enterocolitica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:VO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

YOPH_YEREN Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

Contents


PDB ID 2i42

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OCA

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