2m0r

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Solution structure and dynamics of human S100A14

Structural highlights

2m0r is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

S10AE_HUMAN Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.[1] [2] [3]

Publication Abstract from PubMed

Human S100A14 is a member of the EF-hand calcium-binding protein family that has only recently been described in terms of its functional and pathological properties. The protein is overexpressed in a variety of tumor cells and it has been shown to trigger receptor for advanced glycation end products (RAGE)-dependent signaling in cell cultures. The solution structure of homodimeric S100A14 in the apo state has been solved at physiological temperature. It is shown that the protein does not bind calcium(II) ions and exhibits a "semi-open" conformation that thus represents the physiological structure of the S100A14. The lack of two ligands in the canonical EF-hand calcium(II)-binding site explains the negligible affinity for calcium(II) in solution, and the exposed cysteines and histidine account for the observed precipitation in the presence of zinc(II) or copper(II) ions.

Solution structure and dynamics of human S100A14.,Bertini I, Borsi V, Cerofolini L, Das Gupta S, Fragai M, Luchinat C J Biol Inorg Chem. 2012 Nov 30. PMID:23197251[4]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Jin Q, Chen H, Luo A, Ding F, Liu Z. S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). PLoS One. 2011 Apr 29;6(4):e19375. doi: 10.1371/journal.pone.0019375. PMID:21559403 doi:http://dx.doi.org/10.1371/journal.pone.0019375
  2. ↑ Sapkota D, Costea DE, Blo M, Bruland O, Lorens JB, Vasstrand EN, Ibrahim SO. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. Oral Oncol. 2012 Mar;48(3):219-25. doi: 10.1016/j.oraloncology.2011.10.001. Epub , 2011 Oct 26. PMID:22032898 doi:http://dx.doi.org/10.1016/j.oraloncology.2011.10.001
  3. ↑ Chen H, Yuan Y, Zhang C, Luo A, Ding F, Ma J, Yang S, Tian Y, Tong T, Zhan Q, Liu Z. Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation. J Biol Chem. 2012 May 18;287(21):17109-19. doi: 10.1074/jbc.M111.326975. Epub, 2012 Mar 26. PMID:22451655 doi:http://dx.doi.org/10.1074/jbc.M111.326975
  4. ↑ Bertini I, Borsi V, Cerofolini L, Das Gupta S, Fragai M, Luchinat C. Solution structure and dynamics of human S100A14. J Biol Inorg Chem. 2012 Nov 30. PMID:23197251 doi:10.1007/s00775-012-0963-3

Contents


PDB ID 2m0r

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