2mgn

From Proteopedia

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

Structural highlights

2mgn is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Ligands:	PQ3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive pi-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.,Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

10 reviews cite this structure

G-quadruplex interacting small molecules and drugs: from bench toward bedside.

Müller et al. (2014)

9 more

65 other articles

No citations found

References

↑ Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT. Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3. Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977 doi:http://dx.doi.org/10.1002/anie.201308063

1 Structural highlights
2 Publication Abstract from PubMed
3 References

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PDB ID 2mgn

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2mgn

From Proteopedia

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

Structural highlights

Publication Abstract from PubMed

References

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