2mgq

Structural highlights

Function

HM37_CAEEL Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons.^{[1] [2]}

References

1. ↑ Kim SH, Hwang SB, Chung IK, Lee J. Sequence-specific binding to telomeric DNA by CEH-37, a homeodomain protein in the nematode Caenorhabditis elegans. J Biol Chem. 2003 Jul 25;278(30):28038-44. Epub 2003 Apr 23. PMID:12711598 doi:http://dx.doi.org/10.1074/jbc.M302192200
2. ↑ Lanjuin A, VanHoven MK, Bargmann CI, Thompson JK, Sengupta P. Otx/otd homeobox genes specify distinct sensory neuron identities in C. elegans. Dev Cell. 2003 Oct;5(4):621-33. PMID:14536063