2r9r

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Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit

Structural highlights

2r9r is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:K, NAP, PGW
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCAB2_RAT Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Voltage-dependent K+ (Kv) channels repolarize the action potential in neurons and muscle. This type of channel is gated directly by membrane voltage through protein domains known as voltage sensors, which are molecular voltmeters that read the membrane voltage and regulate the pore. Here we describe the structure of a chimaeric voltage-dependent K+ channel, which we call the 'paddle-chimaera channel', in which the voltage-sensor paddle has been transferred from Kv2.1 to Kv1.2. Crystallized in complex with lipids, the complete structure at 2.4 angstrom resolution reveals the pore and voltage sensors embedded in a membrane-like arrangement of lipid molecules. The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating.

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.,Long SB, Tao X, Campbell EB, MacKinnon R Nature. 2007 Nov 15;450(7168):376-82. PMID:18004376[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
180 reviews cite this structure
Inwardly rectifying potassium channels: their structure, function, and physiological roles.
Hibino et al. (2010)
179 more
557 other articles
No citations found

See Also

References

  1. ↑ Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 2007 Nov 15;450(7168):376-82. PMID:18004376 doi:http://dx.doi.org/10.1038/nature06265

Contents


PDB ID 2r9r

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