2rup

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Solution structure of rat P2X4 receptor head domain

Structural highlights

2rup is a 1 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

P2RX4_RAT Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

Publication Abstract from PubMed

The P2X receptor is an ATP-gated cation channel expressed on the plasma membrane. The head domain (Gln111-Val167 in the rat P2X4 receptor) regulates ATP-induced cation influx. In this study, we prepared a head domain with three disulfide bonds, such as the intact rat P2X4 receptor contains. NMR analysis showed that the head domain possessed the same fold as in the zebrafish P2X4 receptor previously determined by crystallography. Furthermore, the inhibitory, divalent, metal ion binding sites were determined by NMR techniques. These findings will be useful for the design of specific inhibitors for the P2X receptor family.

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding.,Igawa T, Abe Y, Tsuda M, Inoue K, Ueda T FEBS Lett. 2015 Mar 12;589(6):680-6. doi: 10.1016/j.febslet.2015.01.034. Epub, 2015 Feb 4. PMID:25662851[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
6 reviews cite this structure
P2X4: A fast and sensitive purinergic receptor.
Suurväli et al. (2017)
5 more
6 other articles
No citations found

See Also

References

  1. ↑ Igawa T, Abe Y, Tsuda M, Inoue K, Ueda T. Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding. FEBS Lett. 2015 Mar 12;589(6):680-6. doi: 10.1016/j.febslet.2015.01.034. Epub, 2015 Feb 4. PMID:25662851 doi:http://dx.doi.org/10.1016/j.febslet.2015.01.034

Contents


PDB ID 2rup

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OCA

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