2yun

From Proteopedia

Solution structure of the SH3 domain of human Nostrin

Structural highlights

2yun is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NOSTN_HUMAN Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.^[1] ^[2] ^[3]

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Zimmermann K, Opitz N, Dedio J, Renne C, Muller-Esterl W, Oess S. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17167-72. Epub 2002 Nov 21. PMID:12446846 doi:http://dx.doi.org/10.1073/pnas.252345399
↑ Icking A, Matt S, Opitz N, Wiesenthal A, Muller-Esterl W, Schilling K. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci. 2005 Nov 1;118(Pt 21):5059-69. Epub 2005 Oct 18. PMID:16234328 doi:http://dx.doi.org/jcs.02620
↑ Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Muller-Esterl W, Icking A. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell. 2006 Sep;17(9):3870-80. Epub 2006 Jun 28. PMID:16807357 doi:http://dx.doi.org/E05-08-0709

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 References

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PDB ID 2yun

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2yun

From Proteopedia

Solution structure of the SH3 domain of human Nostrin

Structural highlights

Function

Evolutionary Conservation

References

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