3dr6

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Structure of yncA, a putative ACETYLTRANSFERASE from Salmonella typhimurium

Structural highlights

3dr6 is a 3 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Ligands:EDO, GOL, MSE
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

MDDA_SALTY Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), a rare amino acid which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of MSX. It can also use L-methionine sulfone (MSO) (PubMed:25368301). Also catalyzes the acylation of free L-amino acids using an acyl-CoA as acyl donor (By similarity).[UniProtKB:P76112][1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Hentchel KL, Escalante-Semerena JC. In Salmonella enterica, the Gcn5-related acetyltransferase MddA (formerly YncA) acetylates methionine sulfoximine and methionine sulfone, blocking their toxic effects. J Bacteriol. 2015 Jan;197(2):314-25. PMID:25368301 doi:10.1128/JB.02311-14

Contents


PDB ID 3dr6

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OCA

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