3hd4

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MHV Nucleocapsid Protein NTD

Structural highlights

3hd4 is a 1 chain structure with sequence from Murine hepatitis virus strain A59. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.747Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NCAP_CVMA5 Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication. Induces transcription of the prothrombinase (FGL2) and elevates procoagulant activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Ning Q, Lakatoo S, Liu M, Yang W, Wang Z, Phillips MJ, Levy GA. Induction of prothrombinase fgl2 by the nucleocapsid protein of virulent mouse hepatitis virus is dependent on host hepatic nuclear factor-4 alpha. J Biol Chem. 2003 May 2;278(18):15541-9. Epub 2003 Feb 19. PMID:12594208 doi:http://dx.doi.org/10.1074/jbc.M212806200

Contents


PDB ID 3hd4

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