3j2u

Structural highlights

Function

KI10A_DROME Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux".^[1]

See Also

• Kinesin 3D Structures
• Tubulin 3D Structures

References

1. ↑ Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale RD, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22;427(6972):364-70. Epub 2003 Dec 14. PMID:14681690 doi:10.1038/nature02256