3jb9

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Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution

Structural highlights

3jb9 is a 17 chain structure with sequence from Schizosaccharomyces pombe and Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.6Å
Experimental data:Check to display Experimental Data
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SPP42_SCHPO Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region.[1]

See Also

References

  1. ↑ Bottner CA, Schmidt H, Vogel S, Michele M, Kaufer NF. Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe. Curr Genet. 2005 Sep;48(3):151-61. Epub 2005 Oct 12. PMID:16133344 doi:http://dx.doi.org/10.1007/s00294-005-0013-6

Contents


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3jb9, resolution 3.60Å

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