3sb9

From Proteopedia

Cu-mediated Dimer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization

Structural highlights

3sb9 is a 2 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.45Å
Ligands:	CU, FMT
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.^[1]

References

↑ Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

1 Structural highlights
2 Function
3 See Also
4 References

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PDB ID 3sb9

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3sb9

From Proteopedia

Cu-mediated Dimer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization

Structural highlights

Function

See Also

References

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