Structural highlights
Function
CBBX_CERSP ATPase involved in the activation of red-type RuBisCo (ribulose-1,5-bisphosphate carboxylase/oxygenase), which tends to form inactive complexes with its substrate ribulose 1,5-bisphosphate (RuBP) (PubMed:27872295, PubMed:22048315). Catalyzes the release of RuBP from inhibited RuBisCo in an ATP-dependent manner (PubMed:27872295, PubMed:22048315). Activation of RuBisCO involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure (PubMed:27872295, PubMed:22048315).[1] [2]
References
- ↑ Mueller-Cajar O, Stotz M, Wendler P, Hartl FU, Bracher A, Hayer-Hartl M. Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature. 2011 Nov 2;479(7372):194-9. doi: 10.1038/nature10568. PMID:22048315 doi:10.1038/nature10568
- ↑ Loganathan N, Tsai YC, Mueller-Cajar O. Characterization of the heterooligomeric red-type rubisco activase from red algae. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14019-14024. PMID:27872295 doi:10.1073/pnas.1610758113