3szw

Structural highlights

Function

SQRD_ACIF2 Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.^{[1] [2]}

References

1. ↑ Cherney MM, Zhang Y, Solomonson M, Weiner JH, James MN. Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification. J Mol Biol. 2010 Apr 30;398(2):292-305. Epub 2010 Mar 19. PMID:20303979 doi:10.1016/j.jmb.2010.03.018
2. ↑ Cherney MM, Zhang Y, James MN, Weiner JH. Structure-activity characterization of sulfide:quinone oxidoreductase variants. J Struct Biol. 2012 Apr 19. PMID:22542586 doi:10.1016/j.jsb.2012.04.007