3t7j

Structural highlights

Function

RT107_YEAST Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.^{[1] [2]}

References

1. ↑ Rouse J. Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J. 2004 Mar 10;23(5):1188-97. Epub 2004 Feb 26. PMID:14988729 doi:http://dx.doi.org/10.1038/sj.emboj.7600129
2. ↑ Roberts TM, Zaidi IW, Vaisica JA, Peter M, Brown GW. Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase. Mol Biol Cell. 2008 Jan;19(1):171-80. Epub 2007 Oct 31. PMID:17978089 doi:http://dx.doi.org/10.1091/mbc.E07-09-0961