3zr9

From Proteopedia

Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)

Structural highlights

3zr9 is a 1 chain structure with sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.91Å
Ligands:	CD, CO, NI, ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BLAN1_KLEPN Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.

Publication Abstract from PubMed

Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-beta-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.

Structure of New Delhi metallo-beta-lactamase 1 (NDM-1).,Green VL, Verma A, Owens RJ, Phillips SE, Carr SB Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt, 10):1160-4. Epub 2011 Sep 6. PMID:22102018^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

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References

↑ Green VL, Verma A, Owens RJ, Phillips SE, Carr SB. Structure of New Delhi metallo-beta-lactamase 1 (NDM-1). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt, 10):1160-4. Epub 2011 Sep 6. PMID:22102018 doi:10.1107/S1744309111029654

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

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PDB ID 3zr9

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3zr9

From Proteopedia

Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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