4bts

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THE CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH EIF1 AND EIF1A

Structural highlights

4bts is a 40 chain structure with sequence from Tetrahymena thermophila and Tetrahymena thermophila SB210. This structure supersedes the now removed PDB entries 4bpe, 4bpn, 4bpo and 4bpp. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.703Å
Ligands:MG, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

I7MK25_TETTS Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).[RuleBase:RU004365]

Publication Abstract from PubMed

Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 A. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.

The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A.,Weisser M, Voigts-Hoffmann F, Rabl J, Leibundgut M, Ban N Nat Struct Mol Biol. 2013 Jul 14. doi: 10.1038/nsmb.2622. PMID:23851459[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
16 reviews cite this structure
The scanning mechanism of eukaryotic translation initiation.
Hinnebusch et al. (2014)
15 more
41 other articles
No citations found

See Also

References

  1. ↑ Weisser M, Voigts-Hoffmann F, Rabl J, Leibundgut M, Ban N. The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A. Nat Struct Mol Biol. 2013 Jul 14. doi: 10.1038/nsmb.2622. PMID:23851459 doi:10.1038/nsmb.2622

Contents


PDB ID 4bts

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