4djk

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Structure of glutamate-GABA antiporter GadC

Structural highlights

4djk is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.097Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GADC_ECOLI Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.

Contents


PDB ID 4djk

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OCA

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