4e20

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Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor

Structural highlights

4e20 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:0MY
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYK2_MOUSE Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.

See Also

Contents


PDB ID 4e20

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