Structural highlights
Function
RAYT_ECOLI Transposase that is always flanked by repeated extragenic palindrome (REP) sequences, which are clustered in structures called bacterial interspersed mosaic elements (BIMEs). RayT catalyzes cleavage and recombination of BIMEs. Binds REP sequences and cleaves BIMEs both upstream and downstream of the REP sequence. Could be important in the creation of BIME variability and amplification.[1] [2] [3]
References
- ↑ Nunvar J, Huckova T, Licha I. Identification and characterization of repetitive extragenic palindromes (REP)-associated tyrosine transposases: implications for REP evolution and dynamics in bacterial genomes. BMC Genomics. 2010 Jan 19;11:44. doi: 10.1186/1471-2164-11-44. PMID:20085626 doi:http://dx.doi.org/10.1186/1471-2164-11-44
- ↑ Ton-Hoang B, Siguier P, Quentin Y, Onillon S, Marty B, Fichant G, Chandler M. Structuring the bacterial genome: Y1-transposases associated with REP-BIME sequences. Nucleic Acids Res. 2012 Apr;40(8):3596-609. doi: 10.1093/nar/gkr1198. Epub 2011, Dec 22. PMID:22199259 doi:http://dx.doi.org/10.1093/nar/gkr1198
- ↑ Messing SA, Ton-Hoang B, Hickman AB, McCubbin AJ, Peaslee GF, Ghirlando R, Chandler M, Dyda F. The processing of repetitive extragenic palindromes: the structure of a repetitive extragenic palindrome bound to its associated nuclease. Nucleic Acids Res. 2012 Aug 9. PMID:22885300 doi:10.1093/nar/gks741
