4f96

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Crystal Structure of VldE, the pseudo-glycosyltransferase, in complex with GDP

Structural highlights

4f96 is a 2 chain structure with sequence from Streptomyces hygroscopicus subsp. limoneus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.152Å
Ligands:CL, GDP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VLDE_STRHL Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16725283). Catalyzes the condensation between GDP-valienol and validamine 7-phosphate via a nonglycosidic C-N bond formation to yield validoxylamine A 7'-phosphate (PubMed:21766819).[1] [2]

See Also

References

  1. ↑ Singh D, Seo MJ, Kwon HJ, Rajkarnikar A, Kim KR, Kim SO, Suh JW. Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704). Gene. 2006 Jul 5;376(1):13-23. doi: 10.1016/j.gene.2005.12.035. Epub 2006 Apr 5. PMID:16725283 doi:http://dx.doi.org/10.1016/j.gene.2005.12.035
  2. ↑ Asamizu S, Yang J, Almabruk KH, Mahmud T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J Am Chem Soc. 2011 Aug 10;133(31):12124-35. doi: 10.1021/ja203574u. Epub 2011, Jul 18. PMID:21766819 doi:http://dx.doi.org/10.1021/ja203574u

Contents


PDB ID 4f96

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