4gac

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High resolution structure of mouse aldehyde reductase (AKR1a4) in its apo-form

Structural highlights

4gac is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.64Å
Ligands:EDO, FLC
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AK1A1_MOUSE Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).

See Also

Contents


PDB ID 4gac

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OCA

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