4jmr

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A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid

Structural highlights

4jmr is a 8 chain structure with sequence from Human foamy virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GAG_FOAMV Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome.[1] [2]

See Also

References

  1. ↑ Cartellieri M, Herchenroder O, Rudolph W, Heinkelein M, Lindemann D, Zentgraf H, Rethwilm A. N-terminal Gag domain required for foamy virus particle assembly and export. J Virol. 2005 Oct;79(19):12464-76. PMID:16160174 doi:79/19/12464
  2. ↑ Petit C, Giron ML, Tobaly-Tapiero J, Bittoun P, Real E, Jacob Y, Tordo N, De The H, Saib A. Targeting of incoming retroviral Gag to the centrosome involves a direct interaction with the dynein light chain 8. J Cell Sci. 2003 Aug 15;116(Pt 16):3433-42. PMID:12857789 doi:http://dx.doi.org/10.1242/jcs.00613

Contents


PDB ID 4jmr

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OCA

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