4kuz

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Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form

Structural highlights

4kuz is a 2 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Three Fab structures used as targets in the Antibody Modeling Assessment presented a challenge for modeling CDR-L3 due to deviations from the most typical canonical structure. In all three antibodies CDR-L3 has eight residues, which is one residue shorter than usual, and has a conformation that is rarely observed in crystal structures. We analyzed the sequence and structural determinants of this conformation and found that the "short" CDR-L3 is remarkably rigid and retains the conformation in the interactions with antigens and neighboring CDRs. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.

Structural evidence for a constrained conformation of short CDR-L3 in antibodies.,Teplyakov A, Obmolova G, Malia TJ, Luo J, Gilliland GL Proteins. 2014 Jan 27. doi: 10.1002/prot.24522. PMID:24470236[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
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Second antibody modeling assessment (AMA-II).
Almagro et al. (2014)
-1 more
3 other articles
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See Also

References

  1. ↑ Teplyakov A, Obmolova G, Malia TJ, Luo J, Gilliland GL. Structural evidence for a constrained conformation of short CDR-L3 in antibodies. Proteins. 2014 Jan 27. doi: 10.1002/prot.24522. PMID:24470236 doi:http://dx.doi.org/10.1002/prot.24522

Contents


PDB ID 4kuz

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