4lku

Structural highlights

Function

MSCL_ECOLI Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. Participates in the regulation of osmotic pressure changes within the cell. Opens at a pressure just below that which would cause cell disruption and death. The force required to trigger channel opening depends on the membrane lipids composition.^{[1] [2] [3] [4] [5]}

See Also

• Ion channels 3D structures

References

1. ↑ Levina N, Totemeyer S, Stokes NR, Louis P, Jones MA, Booth IR. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. EMBO J. 1999 Apr 1;18(7):1730-7. PMID:10202137 doi:http://dx.doi.org/10.1093/emboj/18.7.1730
2. ↑ Yang LM, Zhong D, Blount P. Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity. Cell Rep. 2013 Feb 21;3(2):520-7. doi: 10.1016/j.celrep.2013.01.018. Epub 2013 , Feb 14. PMID:23416054 doi:http://dx.doi.org/10.1016/j.celrep.2013.01.018
3. ↑ Zhong D, Blount P. Phosphatidylinositol is crucial for the mechanosensitivity of Mycobacterium tuberculosis MscL. Biochemistry. 2013 Aug 13;52(32):5415-20. doi: 10.1021/bi400790j. Epub 2013 Aug , 1. PMID:23875651 doi:http://dx.doi.org/10.1021/bi400790j
4. ↑ Sukharev SI, Blount P, Martinac B, Blattner FR, Kung C. A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature. 1994 Mar 17;368(6468):265-8. PMID:7511799 doi:http://dx.doi.org/10.1038/368265a0
5. ↑ Moe PC, Blount P, Kung C. Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation. Mol Microbiol. 1998 May;28(3):583-92. doi: 10.1046/j.1365-2958.1998.00821.x. PMID:9632260 doi:http://dx.doi.org/10.1046/j.1365-2958.1998.00821.x