Structural highlights
Function
VIRF2_HHV8P Plays a role in the inhibition of host immune response. Acts by interacting with host EIF2AK2/PKR and inhibiting its activation. In turn, EIF2AK2/PKR substrates including EIF2S1 or histone H2A are not phosphorylated.[1]
References
- ↑ Burysek L, Pitha PM. Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase. J Virol. 2001 Mar;75(5):2345-52. PMID:11160738 doi:http://dx.doi.org/10.1128/JVI.75.5.2345-2352.2001
