4qau

From Proteopedia

Crystal structure of F43Y mutant of sperm whale myoglobin

Structural highlights

4qau is a 1 chain structure with sequence from Physeter catodon. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.597Å
Ligands:	HEM
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MYG_PHYMC Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Publication Abstract from PubMed

Heme post-translational modification plays a key role in tuning the structure and function of heme proteins. We herein report a novel tyrosine-heme covalent CO bond in an artificially produced sperm whale myoglobin (Mb) mutant, F43Y Mb, which formed spontaneously in vivo between the Tyr43 hydroxy group and the heme 4-vinyl group. This highlights the diverse chemistry of heme post-translational modifications, and lays groundwork for further investigation of the structural and functional diversity of covalently-bound heme proteins.

A Novel Tyrosine-Heme CO Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins.,Yan DJ, Li W, Xiang Y, Wen GB, Lin YW, Tan X Chembiochem. 2015 Jan 2;16(1):47-50. doi: 10.1002/cbic.201402504. Epub 2014 Nov, 12. PMID:25392956^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

1 reviews cite this structure

Rational Design of Artificial Metalloproteins and Metalloenzymes with Metal Clusters.

Lin et al. (2019)

0 more

12 other articles

No citations found

References

↑ Yan DJ, Li W, Xiang Y, Wen GB, Lin YW, Tan X. A Novel Tyrosine-Heme CO Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins. Chembiochem. 2015 Jan 2;16(1):47-50. doi: 10.1002/cbic.201402504. Epub 2014 Nov, 12. PMID:25392956 doi:http://dx.doi.org/10.1002/cbic.201402504

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

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PDB ID 4qau

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Categories: Large Structures | Physeter catodon | Li W | Lin Y | Tan X

4qau

From Proteopedia

Crystal structure of F43Y mutant of sperm whale myoglobin

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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