4uf2

Structural highlights

Function

DPV22_DPV83 Plays a role in the inhibition of host apoptosis by sequestering and inactivating several proapoptotic BCL-2 proteins, including BAK1 and BAX. Prevents the conformational activation of both of them.^[1]

References

1. ↑ Banadyga L, Lam SC, Okamoto T, Kvansakul M, Huang DC, Barry M. Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax. J Virol. 2011 Mar;85(5):1922-34. PMID:21159883 doi:10.1128/JVI.01959-10