4y61

From Proteopedia

Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1

Structural highlights

4y61 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.358Å
Ligands:	NAG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTPRD_MOUSE

Publication Abstract from PubMed

Selective binding between pre- and postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) delta. The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

Structure of Slitrk2-PTPdelta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.,Yamagata A, Sato Y, Goto-Ito S, Uemura T, Maeda A, Shiroshima T, Yoshida T, Fukai S Sci Rep. 2015 May 19;5:9686. doi: 10.1038/srep09686. PMID:25989451^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

7 reviews cite this structure

PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes.

Uhl et al. (2019)

6 more

22 other articles

No citations found

References

↑ Yamagata A, Sato Y, Goto-Ito S, Uemura T, Maeda A, Shiroshima T, Yoshida T, Fukai S. Structure of Slitrk2-PTPdelta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion. Sci Rep. 2015 May 19;5:9686. doi: 10.1038/srep09686. PMID:25989451 doi:http://dx.doi.org/10.1038/srep09686

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

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PDB ID 4y61

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4y61

From Proteopedia

Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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