4ybb

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High-resolution structure of the Escherichia coli ribosome

Structural highlights

4ybb is a 18 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:1MG, 1PE, 2MA, 2MG, 3TD, 4D4, 4OC, 5MC, 5MU, 6MZ, ACY, D2T, EDO, G7M, GUN, H2U, MA6, MEQ, MG, MPD, OMC, OMG, OMU, PEG, PG4, PGE, PSU, PUT, SPD, TRS, UR3, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RL33_ECOLI

Publication Abstract from PubMed

Protein synthesis by the ribosome is highly dependent on the ionic conditions in the cellular environment, but the roles of ribosome solvation have remained poorly understood. Moreover, the functions of modifications to ribosomal RNA and ribosomal proteins have also been unclear. Here we present the structure of the Escherichia coli 70S ribosome at 2.4-A resolution. The structure reveals details of the ribosomal subunit interface that are conserved in all domains of life, and it suggests how solvation contributes to ribosome integrity and function as well as how the conformation of ribosomal protein uS12 aids in mRNA decoding. This structure helps to explain the phylogenetic conservation of key elements of the ribosome, including post-transcriptional and post-translational modifications, and should serve as a basis for future antibiotic development.

High-resolution structure of the Escherichia coli ribosome.,Noeske J, Wasserman MR, Terry DS, Altman RB, Blanchard SC, Cate JH Nat Struct Mol Biol. 2015 Mar 16. doi: 10.1038/nsmb.2994. PMID:25775265[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
16 reviews cite this structure
Dynamic RNA Modifications in Gene Expression Regulation.
Roundtree et al. (2017)
15 more
66 other articles
No citations found

See Also

References

  1. ↑ Noeske J, Wasserman MR, Terry DS, Altman RB, Blanchard SC, Cate JH. High-resolution structure of the Escherichia coli ribosome. Nat Struct Mol Biol. 2015 Mar 16. doi: 10.1038/nsmb.2994. PMID:25775265 doi:http://dx.doi.org/10.1038/nsmb.2994

Contents


PDB ID 4ybb

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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