4z6k

From Proteopedia

Alcohol dehydrogenase from the antarctic psychrophile Moraxella sp. TAE 123

Structural highlights

4z6k is a 4 chain structure with sequence from Moraxella sp. TAE123. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:	ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADH_MORSE Psychrophilic alcohol dehydrogenase that exhibits a wide range of substrate specificity, oxidizing mainly primary and secondary aliphatic alcohols, utilizing NAD(+) as a cosubstrate. In vitro, shows highest reaction rates for ethanol as a substrate and gradually decreases its reaction rates as the length and branching of the carbon chain of the alcohol substrates increase. To a lesser extent, is also able to reduce aldehydes and ketones. Do not catalyze the further oxidation of aldehydes to carboxylic acids. Cannot use NADP(+) instead of NAD(+).^[1]

References

↑ Tsigos I, Velonia K, Smonou I, Bouriotis V. Purification and characterization of an alcohol dehydrogenase from the Antarctic psychrophile Moraxella sp. TAE123. Eur J Biochem. 1998 Jun 1;254(2):356-62. PMID:9660191 doi:10.1046/j.1432-1327.1998.2540356.x