4zxb

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Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules

Structural highlights

4zxb is a 5 chain structure with sequence from Homo sapiens and Mus musculus. This structure supersedes the now removed PDB entries 2dtg and 3loh. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:BMA, FUC, MAN, NAG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

U5LP42_MOUSE

Publication Abstract from PubMed

Insulin receptor (IR) signaling is critical to controlling nutrient uptake and metabolism. However, only a low-resolution (3.8 A) structure currently exists for the IR ectodomain, with some segments ill-defined or unmodeled due to disorder. Here, we revise this structure using new diffraction data to 3.3 A resolution that allow improved modeling of the N-linked glycans, the first and third fibronectin type III domains, and the insert domain. A novel haptic interactive molecular dynamics strategy was used to aid fitting to low-resolution electron density maps. The resulting model provides a foundation for investigation of structural transitions in IR upon ligand binding.

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.,Croll TI, Smith BJ, Margetts MB, Whittaker J, Weiss MA, Ward CW, Lawrence MC Structure. 2016 Jan 27. pii: S0969-2126(16)00007-1. doi:, 10.1016/j.str.2015.12.014. PMID:26853939[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Croll TI, Smith BJ, Margetts MB, Whittaker J, Weiss MA, Ward CW, Lawrence MC. Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain. Structure. 2016 Jan 27. pii: S0969-2126(16)00007-1. doi:, 10.1016/j.str.2015.12.014. PMID:26853939 doi:http://dx.doi.org/10.1016/j.str.2015.12.014

Contents


PDB ID 4zxb

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OCA

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