5dn7

Structural highlights

Function

TGRM1_MOUSE Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (PubMed:26378256, PubMed:32747439).[UniProtKB:Q17423]^{[1] [2]}

References

1. ↑ Das A, Dickinson DJ, Wood CC, Goldstein B, Slep KC. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Mol Biol Cell. 2015 Sep 16. pii: mbc.E15-08-0603. PMID:26378256 doi:http://dx.doi.org/10.1091/mbc.E15-08-0603
2. ↑ Morbidoni V, Agolini E, Slep KC, Pannone L, Zuccarello D, Cassina M, Grosso E, Gai G, Salviati L, Dallapiccola B, Novelli A, Martinelli S, Trevisson E. Biallelic mutations in the TOGARAM1 gene cause a novel primary ciliopathy. J Med Genet. 2021 Aug;58(8):526-533. PMID:32747439 doi:10.1136/jmedgenet-2020-106833