5ez7

Structural highlights

Function

Y4991_PSEAE Probably functions as a FAD-dependent oxidoreductase, whose physiological substrate is unknown. Does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities (PubMed:26841760). Is essential for growth of P.aeruginosa in the sputum of cystic fibrosis patients (PubMed:25775563).^{[1] [2]}

References

1. ↑ Turner KH, Wessel AK, Palmer GC, Murray JL, Whiteley M. Essential genome of Pseudomonas aeruginosa in cystic fibrosis sputum. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4110-5. PMID:25775563 doi:10.1073/pnas.1419677112
2. ↑ Jacewicz A, Schnell R, Lindqvist Y, Schneider G. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa. Acta Crystallogr F Struct Biol Commun. 2016 Feb 1;72(Pt 2):105-11. doi:, 10.1107/S2053230X15024437. Epub 2016 Jan 22. PMID:26841760 doi:http://dx.doi.org/10.1107/S2053230X15024437