5fir

Structural highlights

Function

XRN2_CAEEL Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.^{[1] [2]}

References

1. ↑ Chatterjee S, Grosshans H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature. 2009 Sep 24;461(7263):546-9. doi: 10.1038/nature08349. Epub 2009 Sep 6. PMID:19734881 doi:http://dx.doi.org/10.1038/nature08349
2. ↑ Chatterjee S, Fasler M, Bussing I, Grosshans H. Target-mediated protection of endogenous microRNAs in C. elegans. Dev Cell. 2011 Mar 15;20(3):388-96. doi: 10.1016/j.devcel.2011.02.008. PMID:21397849 doi:http://dx.doi.org/10.1016/j.devcel.2011.02.008